3N2P
Crystal structure of human carbonic anhydrase II in complex with a benzenesulfonamide inhibitor
Summary for 3N2P
Entry DOI | 10.2210/pdb3n2p/pdb |
Related | 3MZC 3N0N 3N3J 3N4B |
Descriptor | Carbonic anhydrase 2, ZINC ION, 4-{[(3-nitrophenyl)carbamoyl]amino}benzenesulfonamide, ... (6 entities in total) |
Functional Keywords | lyase, zinc metalloenzyme, zinc ligands, benzenesulfonamide, inhibitor., lyase-lyase inhibitor complex, lyase/lyase inhibitor |
Biological source | Homo sapiens |
Cellular location | Cytoplasm : P00918 |
Total number of polymer chains | 1 |
Total formula weight | 29861.02 |
Authors | Avvaru, B.S.,Wagner, J.,Robbins, A.H.,McKenna, R. (deposition date: 2010-05-18, release date: 2011-03-09, Last modification date: 2023-09-06) |
Primary citation | Pacchiano, F.,Aggarwal, M.,Avvaru, B.S.,Robbins, A.H.,Scozzafava, A.,McKenna, R.,Supuran, C.T. Selective hydrophobic pocket binding observed within the carbonic anhydrase II active site accommodate different 4-substituted-ureido-benzenesulfonamides and correlate to inhibitor potency. Chem.Commun.(Camb.), 46:8371-8373, 2010 Cited by PubMed: 20922253DOI: 10.1039/c0cc02707c PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.648 Å) |
Structure validation
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