3MY0

Crystal structure of the ACVRL1 (ALK1) kinase domain bound to LDN-193189

3MY0 の概要

• エントリーDOI: 10.2210/pdb3my0/pdb
• 分子名称: Serine/threonine-protein kinase receptor R3, 4-[6-(4-piperazin-1-ylphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline (3 entities in total)
• 機能のキーワード: protein kinase, serine/threonine-protein kinase receptor, structural genomics, structural genomics consortium, sgc, transferase
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Membrane; Single-pass type I membrane protein: P37023
• タンパク質・核酸の鎖数: 24
• 化学式量合計: 845164.82

構造登録者

Chaikuad, A.,Alfano, I.,Cooper, C.,Mahajan, P.,Daga, N.,Sanvitale, C.,Fedorov, O.,Petrie, K.,Savitsky, P.,Gileadi, O.,Sethi, R.,Krojer, T.,Muniz, J.R.C.,Pike, A.C.W.,Vollmar, M.,Carpenter, C.P.,Ugochukwu, E.,Knapp, S.,von Delft, F.,Weigelt, J.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Bullock, A.,Structural Genomics Consortium (SGC) (登録日: 2010-05-08, 公開日: 2010-07-21, 最終更新日: 2023-11-01)

• 主引用文献: Kerr, G.,Sheldon, H.,Chaikuad, A.,Alfano, I.,von Delft, F.,Bullock, A.N.,Harris, A.L.; A small molecule targeting ALK1 prevents Notch cooperativity and inhibits functional angiogenesis.; Angiogenesis, 18:209-217, 2015; PubMed: 25557927; DOI: 10.1007/s10456-014-9457-y

実験手法

X-RAY DIFFRACTION (2.65 Å)