3MWS

Crystal Structure of Group N HIV-1 Protease

Summary for 3MWS

Entry DOI	10.2210/pdb3mws/pdb
Descriptor	HIV-1 Protease, CHLORIDE ION, (3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL(1S,2R)-3-[[(4-AMINOPHENYL)SULFONYL](ISOBUTYL)AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE, ... (4 entities in total)
Functional Keywords	hiv-1, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Human immunodeficiency virus 1
Total number of polymer chains	2
Total formula weight	22346.42
Authors	Sayer, J.M.,Agniswamy, J.,Weber, I.T.,Louis, J.M. (deposition date: 2010-05-06, release date: 2011-03-23, Last modification date: 2023-09-06)
Primary citation	Sayer, J.M.,Agniswamy, J.,Weber, I.T.,Louis, J.M. Autocatalytic maturation, physical/chemical properties, and crystal structure of group N HIV-1 protease: relevance to drug resistance. Protein Sci., 19:2055-2072, 2010 Cited by PubMed: 20737578 DOI: 10.1002/pro.486 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.09 Å)

Structure validation