3MU6
Inhibiting the Binding of Class IIa Histone Deacetylases to Myocyte Enhancer Factor-2 by Small Molecules
Summary for 3MU6
Entry DOI | 10.2210/pdb3mu6/pdb |
Descriptor | Myocyte-specific enhancer factor 2A, DNA (5'-D(*AP*AP*AP*GP*CP*TP*AP*TP*TP*AP*TP*TP*AP*GP*CP*TP*T)-3'), DNA (5'-D(*TP*AP*AP*GP*CP*TP*AP*AP*TP*AP*AP*TP*AP*GP*CP*TP*T)-3'), ... (4 entities in total) |
Functional Keywords | mads-box/mef2 domain, transcription co-factors, protein-dna complex, protein-protein docking, dna binding protein-dna complex, dna binding protein/dna |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus : Q02078 |
Total number of polymer chains | 8 |
Total formula weight | 54768.84 |
Authors | Jayathilaka, N.,Han, A.,Gaffney, K.,Dey, R.,He, J.,Ye, J.,Gao, T.,Petasis, N.A.,Chen, L. (deposition date: 2010-05-01, release date: 2011-11-02, Last modification date: 2023-09-06) |
Primary citation | Jayathilaka, N.,Han, A.,Gaffney, K.J.,Dey, R.,Jarusiewicz, J.A.,Noridomi, K.,Philips, M.A.,Lei, X.,He, J.,Ye, J.,Gao, T.,Petasis, N.A.,Chen, L. Inhibition of the function of class IIa HDACs by blocking their interaction with MEF2. Nucleic Acids Res., 40:5378-5388, 2012 Cited by PubMed: 22396528DOI: 10.1093/nar/gks189 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.434 Å) |
Structure validation
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