3MU6

Inhibiting the Binding of Class IIa Histone Deacetylases to Myocyte Enhancer Factor-2 by Small Molecules

3MU6 の概要

• エントリーDOI: 10.2210/pdb3mu6/pdb
• 分子名称: Myocyte-specific enhancer factor 2A, DNA (5'-D(*AP*AP*AP*GP*CP*TP*AP*TP*TP*AP*TP*TP*AP*GP*CP*TP*T)-3'), DNA (5'-D(*TP*AP*AP*GP*CP*TP*AP*AP*TP*AP*AP*TP*AP*GP*CP*TP*T)-3'), ... (4 entities in total)
• 機能のキーワード: mads-box/mef2 domain, transcription co-factors, protein-dna complex, protein-protein docking, dna binding protein-dna complex, dna binding protein/dna
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Nucleus : Q02078
• タンパク質・核酸の鎖数: 8
• 化学式量合計: 54768.84

構造登録者

Jayathilaka, N.,Han, A.,Gaffney, K.,Dey, R.,He, J.,Ye, J.,Gao, T.,Petasis, N.A.,Chen, L. (登録日: 2010-05-01, 公開日: 2011-11-02, 最終更新日: 2023-09-06)

• 主引用文献: Jayathilaka, N.,Han, A.,Gaffney, K.J.,Dey, R.,Jarusiewicz, J.A.,Noridomi, K.,Philips, M.A.,Lei, X.,He, J.,Ye, J.,Gao, T.,Petasis, N.A.,Chen, L.; Inhibition of the function of class IIa HDACs by blocking their interaction with MEF2.; Nucleic Acids Res., 40:5378-5388, 2012; PubMed: 22396528; DOI: 10.1093/nar/gks189

実験手法

X-RAY DIFFRACTION (2.434 Å)