Glycogen phosphorylase complexed with 4-methoxybenzaldehyde-4-(2,3,4,6-tetra-O-acetyl-beta-D-glucopyranosyl)-thiosemicarbazone

Summary for 3MRX

Related3MQF 3MRT 3MRV 3MS2 3MS4 3MS7 3MSC 3MT7 3MT8 3MT9 3MTA 3MTB 3MTD
DescriptorGlycogen phosphorylase, muscle form, N-({(2E)-2-[(4-methoxyphenyl)methylidene]hydrazino}carbonothioyl)-beta-D-glucopyranosylamine (3 entities in total)
Functional Keywordsglycogenolysis, type 2 diabetes, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological sourceOryctolagus cuniculus (European rabbit,Japanese white rabbit,domestic rabbit,rabbits)
Total number of polymer chains1
Total molecular weight98262.14
Alexacou, K.-M. (deposition date: 2010-04-29, release date: 2011-01-05, Last modification date: 2019-07-17)
Primary citation
Alexacou, K.M.,Tenchiu Deleanu, A.C.,Chrysina, E.D.,Charavgi, M.D.,Kostas, I.D.,Zographos, S.E.,Oikonomakos, N.G.,Leonidas, D.D.
The binding of beta-D-glucopyranosyl-thiosemicarbazone derivatives to glycogen phosphorylase: a new class of inhibitors
Bioorg.Med.Chem., 18:7911-7922, 2010
PubMed: 20947361 (PDB entries with the same primary citation)
DOI: 10.1016/j.bmc.2010.09.039
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.2162 0.1% 4.7% 5.1%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload
PDB entries from 2020-10-21