3MO0

Human G9a-like (GLP, also known as EHMT1) in complex with inhibitor E11

3MO0 の概要

• エントリーDOI: 10.2210/pdb3mo0/pdb
• 関連するPDBエントリー: 3FPD 3MO2 3MO5
• 分子名称: Histone-lysine N-methyltransferase, H3 lysine-9 specific 5, S-ADENOSYL-L-HOMOCYSTEINE, N~4~-(1-benzylpiperidin-4-yl)-N~2~-[3-(dimethylamino)propyl]-6,7-dimethoxyquinazoline-2,4-diamine, ... (6 entities in total)
• 機能のキーワード: epigenetics, histone lysine methylation, enzymatic inhibition, lysine mimics, transferase
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Nucleus: Q9H9B1
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 68643.38

構造登録者

Chang, Y.,Horton, J.R.,Cheng, X. (登録日: 2010-04-22, 公開日: 2010-06-30, 最終更新日: 2023-09-06)

• 主引用文献: Chang, Y.,Ganesh, T.,Horton, J.R.,Spannhoff, A.,Liu, J.,Sun, A.,Zhang, X.,Bedford, M.T.,Shinkai, Y.,Snyder, J.P.,Cheng, X.; Adding a lysine mimic in the design of potent inhibitors of histone lysine methyltransferases.; J.Mol.Biol., 400:1-7, 2010; PubMed: 20434463; DOI: 10.1016/j.jmb.2010.04.048

実験手法

X-RAY DIFFRACTION (2.78 Å)