3MNN

A Ruthenium Antitumour Agent Forms Specific Histone Protein Adducts in the Nucleosome Core

Summary for 3MNN

• Entry DOI: 10.2210/pdb3mnn/pdb
• Related: 2NZD
• Descriptor: Histone H3.2, 1-methyl-4-(1-methylethyl)benzene, 1,3,5-triaza-7-phosphatricyclo[3.3.1.1~3,7~]decane, ... (12 entities in total)
• Functional Keywords: nucleosome, ncp, ruthenium, rapta-c, structural protein-dna complex, structural protein/dna
• Biological source: Xenopus laevis (African clawed frog); More
• Cellular location: Nucleus: P84233 P62799 P02281
• Total number of polymer chains: 10
• Total formula weight: 197692.83

Authors

Ong, M.S.,Davey, C.A. (deposition date: 2010-04-22, release date: 2011-04-06, Last modification date: 2023-11-01)

• Primary citation: Wu, B.,Ong, M.S.,Groessl, M.,Adhireksan, Z.,Hartinger, C.G.,Dyson, P.J.,Davey, C.A.; A ruthenium antimetastasis agent forms specific histone protein adducts in the nucleosome core; Chemistry, 17:3562-3566, 2011; PubMed: 21344528; DOI: 10.1002/chem.201100298

Experimental method

X-RAY DIFFRACTION (2.5 Å)