3MNN
A Ruthenium Antitumour Agent Forms Specific Histone Protein Adducts in the Nucleosome Core
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, E | Histone H3.2 | polymer | 135 | 15303.9 | 2 | UniProt (P84233) Pfam (PF00125) In PDB | Xenopus laevis (African clawed frog) | |
2 | B, F | Histone H4 | polymer | 102 | 11263.2 | 2 | UniProt (P62799) Pfam (PF15511) In PDB | Xenopus laevis (African clawed frog) | |
3 | C, G | Histone H2A | polymer | 119 | 12941.1 | 2 | UniProt (Q6AZJ8) Pfam (PF00125) Pfam (PF16211) UniProt (by SIFTS) (P06897) In PDB | Xenopus laevis (African clawed frog) | |
4 | D, H | Histone H2B 1.1 | polymer | 125 | 13848.1 | 2 | UniProt (P02281) Pfam (PF00125) In PDB | Xenopus laevis (African clawed frog) | H2B1.1 |
5 | I | DNA (145-MER) | polymer | 145 | 44749.7 | 1 | |||
6 | J | DNA (145-MER) | polymer | 145 | 44740.6 | 1 | |||
7 | D, G, H | SULFATE ION | non-polymer | 96.1 | 3 | Chemie (SO4) | |||
8 | E | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
9 | F, G, H | RUTHENIUM ION | non-polymer | 101.1 | 3 | Chemie (RU) | |||
10 | F, G, H | 1-methyl-4-(1-methylethyl)benzene | non-polymer | 134.2 | 3 | Chemie (MML) | |||
11 | F, G, H | 1,3,5-triaza-7-phosphatricyclo[3.3.1.1~3,7~]decane | non-polymer | 157.2 | 3 | Chemie (PTW) | |||
12 | water | water | 18.0 | 22 | Chemie (HOH) |
Sequence modifications
A, E: 1 - 135 (UniProt: P84233)
D, H: -2 - 122 (UniProt: P02281)
PDB | External Database | Details |
---|---|---|
Ala 102 | Gly 103 | SEE REMARK 999 |
PDB | External Database | Details |
---|---|---|
Thr 29 | Ser 33 | SEE REMARK 999 |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 10 |
Total formula weight | 196203.0 | |
Non-Polymers* | Number of molecules | 13 |
Total formula weight | 1489.8 | |
All* | Total formula weight | 197692.8 |