3MJW

PI3 Kinase gamma with a benzofuranone inhibitor

Summary for 3MJW

Entry DOI	10.2210/pdb3mjw/pdb
Descriptor	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, (2Z)-4,6-dihydroxy-2-[(8-methoxy-1,2,3,4-tetrahydropyrazino[1,2-a]indol-10-yl)methylidene]-1-benzofuran-3(2H)-one (2 entities in total)
Functional Keywords	atp-binding, kinase, nucleotide-binding, transferase
Biological source	Homo sapiens
Total number of polymer chains	1
Total formula weight	111134.54
Authors	Bard, J.,Svenson, K. (deposition date: 2010-04-13, release date: 2010-06-09, Last modification date: 2023-09-06)
Primary citation	Zhang, N.,Ayral-Kaloustian, S.,Anderson, J.T.,Nguyen, T.,Das, S.,Venkatesan, A.M.,Brooijmans, N.,Lucas, J.,Yu, K.,Hollander, I.,Mallon, R. 5-Ureidobenzofuranone indoles as potent and efficacious inhibitors of PI3 kinase-alpha and mTOR for the treatment of breast cancer. Bioorg.Med.Chem.Lett., 20:3526-3529, 2010 Cited by PubMed: 20483602 DOI: 10.1016/j.bmcl.2010.04.139 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.87 Å)

Structure validation