3MI2
Crystal structure of human orotidine-5'-monophosphate decarboxylase complexed with pyrazofurin monophosphate
Summary for 3MI2
Entry DOI | 10.2210/pdb3mi2/pdb |
Related | 2EAW 2P1F 3BGG 3BGJ 3BKO 3BVJ 3G3D 3G3M |
Descriptor | Uridine 5'-monophosphate synthase, (1S)-1,4-anhydro-1-(5-carbamoyl-4-hydroxy-1H-pyrazol-3-yl)-5-O-phosphono-D-ribitol (3 entities in total) |
Functional Keywords | ump synthase, orotidine 5'-monophosphate decarboxylase, pyrazofurin monophosphate, lyase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 61686.72 |
Authors | Liu, Y.,To, T.,Kotra, L.P.,Pai, E.F. (deposition date: 2010-04-09, release date: 2010-05-26, Last modification date: 2024-10-09) |
Primary citation | Meza-Avina, M.E.,Wei, L.,Liu, Y.,Poduch, E.,Bello, A.M.,Mishra, R.K.,Pai, E.F.,Kotra, L.P. Structural determinants for the inhibitory ligands of orotidine-5'-monophosphate decarboxylase. Bioorg.Med.Chem., 18:4032-4041, 2010 Cited by PubMed: 20452222DOI: 10.1016/j.bmc.2010.04.017 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.2 Å) |
Structure validation
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