4H71

Human Plk1-PBD in complex with Poloxime ((E)-4-(hydroxyimino)-2-isopropyl-5-methylcyclohexa-2,5-dienone)

Replaces:  3MHN

Summary for 4H71

• Entry DOI: 10.2210/pdb4h71/pdb
• Related: 4H5X 4H70
• Descriptor: Serine/threonine-protein kinase PLK1, GLYCEROL, 2-methyl-5-(1-methylethyl)cyclohexa-2,5-diene-1,4-dione 1-oxime, ... (4 entities in total)
• Functional Keywords: kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Nucleus: P53350
• Total number of polymer chains: 2
• Total formula weight: 55360.06

Authors

Yin, Z.,Rehse, P.H. (deposition date: 2012-09-19, release date: 2012-10-03, Last modification date: 2023-11-08)

• Primary citation: Yin, Z.,Song, Y.,Rehse, P.H.; Thymoquinone Blocks pSer/pThr Recognition by Plk1 Polo-Box Domain As a Phosphate Mimic; Acs Chem.Biol., 8:303-308, 2013; PubMed: 23135290; DOI: 10.1021/cb3004379

Experimental method

X-RAY DIFFRACTION (1.93 Å)