4H71
Human Plk1-PBD in complex with Poloxime ((E)-4-(hydroxyimino)-2-isopropyl-5-methylcyclohexa-2,5-dienone)
Replaces: 3MHNEntity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (B, A) | Serine/threonine-protein kinase PLK1 | polymer | 240 | 27544.4 | 2 | UniProt (P53350) Pfam (PF00659) | Homo sapiens (human) | Polo-like kinase 1, PLK-1, Serine/threonine-protein kinase 13, STPK13 |
| 2 | C (A) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 3 | D (A) | 2-methyl-5-(1-methylethyl)cyclohexa-2,5-diene-1,4-dione 1-oxime | non-polymer | 179.2 | 1 | Chemie (PXE) | |||
| 4 | E, F (B, A) | water | water | 18.0 | 318 | Chemie (HOH) |
Sequence modifications
B, A: 367 - 603 (UniProt: P53350)
| PDB | External Database | Details |
|---|---|---|
| Ser 364 | - | expression tag |
| Asn 365 | - | expression tag |
| Ala 366 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 55088.7 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 271.3 | |
| All* | Total formula weight | 55360.1 |
