3MCO

Crystal Structure of the 6-hyroxymethyl-7,8-dihydropterin pyrophosphokinase dihydropteroate synthase bifunctional enzyme from Francisella tularensis

Summary for 3MCO

• Entry DOI: 10.2210/pdb3mco/pdb
• Related: 3MCM 3MCN
• Descriptor: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase/dihydropteroate synthase, 2-AMINO-6-HYDROXYMETHYL-7,8-DIHYDRO-3H-PTERIDIN-4-ONE, DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER, ... (5 entities in total)
• Functional Keywords: folate, tim barrel, kinase, synthase, hppk, dhps, pterin, transferase
• Biological source: Francisella tularensis subsp. holarctica
• Total number of polymer chains: 2
• Total formula weight: 103062.86

Authors

Pemble IV, C.W.,Mehta, P.K.,Mehra, S.,Li, Z.,Lee, R.E.,White, S.W. (deposition date: 2010-03-29, release date: 2010-12-22, Last modification date: 2023-09-06)

• Primary citation: Pemble, C.W.,Mehta, P.K.,Mehra, S.,Li, Z.,Nourse, A.,Lee, R.E.,White, S.W.; Crystal structure of the 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase.dihydropteroate synthase bifunctional enzyme from Francisella tularensis.; Plos One, 5:e14165-e14165, 2010; PubMed: 21152407; DOI: 10.1371/journal.pone.0014165

Experimental method

X-RAY DIFFRACTION (2.3 Å)