3MCO

Crystal Structure of the 6-hyroxymethyl-7,8-dihydropterin pyrophosphokinase dihydropteroate synthase bifunctional enzyme from Francisella tularensis

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase/dihydropteroate synthase	polymer	442	50587.3	2	UniProt (Q2A2W3) In PDB	Francisella tularensis subsp. holarctica
2	A, B	2-AMINO-6-HYDROXYMETHYL-7,8-DIHYDRO-3H-PTERIDIN-4-ONE	non-polymer		195.2	4	Chemie (PH2)
3	A, B	DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER	non-polymer		505.2	2	Chemie (APC)
4	A, B	MAGNESIUM ION	non-polymer		24.3	4	Chemie (MG)
5		water	water		18.0	57	Chemie (HOH)

Sequence modifications

A, B: 3 - 422 (UniProt: Q2A2W3)

PDB	External Database	Details
Met -19	-	expression tag
Gly -18	-	expression tag
Ser -17	-	expression tag
Ser -16	-	expression tag
His -15	-	expression tag
His -14	-	expression tag
His -13	-	expression tag
His -12	-	expression tag
His -11	-	expression tag
His -10	-	expression tag
Ser -9	-	expression tag
Ser -8	-	expression tag
Gly -7	-	expression tag
Leu -6	-	expression tag
Val -5	-	expression tag
Pro -4	-	expression tag
Arg -3	-	expression tag
Gly -2	-	expression tag
Ser -1	-	expression tag
His 0	-	expression tag
Met 1	-	expression tag
Val 2	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	101174.5
Non-Polymers*	Number of molecules	10
	Total formula weight	1888.4
All*	Total formula weight	103062.9

*Water molecules are not included.