3MB9

Human Aldose Reductase mutant T113A complexed with Zopolrestat

Summary for 3MB9

• Entry DOI: 10.2210/pdb3mb9/pdb
• Related: 2FZ8 2FZ9 3LEN 3LQG 3LQL 3M0I
• Descriptor: Aldose reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 3,4-DIHYDRO-4-OXO-3-((5-TRIFLUOROMETHYL-2-BENZOTHIAZOLYL)METHYL)-1-PHTHALAZINE ACETIC ACID, ... (4 entities in total)
• Functional Keywords: t113a mutant, oxidoreductase, tim barrel, nadp, phosphoprotein, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm: P15121
• Total number of polymer chains: 1
• Total formula weight: 37031.09

Authors

Koch, C.,Heine, A.,Klebe, G. (deposition date: 2010-03-25, release date: 2011-03-09, Last modification date: 2024-05-29)

• Primary citation: Koch, C.,Heine, A.,Klebe, G.; Ligand-induced fit affects binding modes and provokes changes in crystal packing of aldose reductase; Biochim.Biophys.Acta, 1810:879-887, 2011; PubMed: 21684320; DOI: 10.1016/j.bbagen.2011.06.001

Experimental method

X-RAY DIFFRACTION (1.65 Å)