2FZ8
Human Aldose reductase complexed with inhibitor zopolrestat at 1.48 A(1 day soaking).
Summary for 2FZ8
Entry DOI | 10.2210/pdb2fz8/pdb |
Related | 1MAR 2FZ9 2FZB 2FZD |
Descriptor | aldose reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 3,4-DIHYDRO-4-OXO-3-((5-TRIFLUOROMETHYL-2-BENZOTHIAZOLYL)METHYL)-1-PHTHALAZINE ACETIC ACID, ... (4 entities in total) |
Functional Keywords | tim-barrel, backbone flip, oxidoreductase |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: P15121 |
Total number of polymer chains | 1 |
Total formula weight | 37061.12 |
Authors | Steuber, H.,Zentgraf, M.,Gerlach, C.,Sotriffer, C.A.,Heine, A.,Klebe, G. (deposition date: 2006-02-09, release date: 2006-10-03, Last modification date: 2023-08-30) |
Primary citation | Steuber, H.,Zentgraf, M.,Gerlach, C.,Sotriffer, C.A.,Heine, A.,Klebe, G. Expect the Unexpected or Caveat for Drug Designers: Multiple Structure Determinations Using Aldose Reductase Crystals Treated under Varying Soaking and Co-crystallisation Conditions. J.Mol.Biol., 363:174-187, 2006 Cited by PubMed: 16952371DOI: 10.1016/j.jmb.2006.08.011 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.48 Å) |
Structure validation
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