3MB9

Human Aldose Reductase mutant T113A complexed with Zopolrestat

3MB9 の概要

• エントリーDOI: 10.2210/pdb3mb9/pdb
• 関連するPDBエントリー: 2FZ8 2FZ9 3LEN 3LQG 3LQL 3M0I
• 分子名称: Aldose reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 3,4-DIHYDRO-4-OXO-3-((5-TRIFLUOROMETHYL-2-BENZOTHIAZOLYL)METHYL)-1-PHTHALAZINE ACETIC ACID, ... (4 entities in total)
• 機能のキーワード: t113a mutant, oxidoreductase, tim barrel, nadp, phosphoprotein, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm: P15121
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 37031.09

構造登録者

Koch, C.,Heine, A.,Klebe, G. (登録日: 2010-03-25, 公開日: 2011-03-09, 最終更新日: 2024-05-29)

主引用文献

Koch, C.,Heine, A.,Klebe, G.
Ligand-induced fit affects binding modes and provokes changes in crystal packing of aldose reductase
Biochim.Biophys.Acta, 1810:879-887, 2011

PubMed Abstract: Flexibility is a common feature of proteins. For human aldose reductase, a variety of conformers have been observed in crystalline complexes with different inhibitors.

PubMed: 21684320
DOI: 10.1016/j.bbagen.2011.06.001

実験手法

X-RAY DIFFRACTION (1.65 Å)