3M6B
Crystal Structure of the Ertapenem Pre-isomerized Covalent Adduct with TB B-lactamase
Summary for 3M6B
Entry DOI | 10.2210/pdb3m6b/pdb |
Related | 3cg5 3dwz 3M6H |
Descriptor | Beta-lactamase, PHOSPHATE ION, (4R,5S)-3-({(3S,5S)-5-[(3-carboxyphenyl)carbamoyl]pyrrolidin-3-yl}sulfanyl)-5-[(1S,2R)-1-formyl-2-hydroxypropyl]-4-methyl-4,5-dihydro-1H-pyrrole-2-carboxylic acid, ... (4 entities in total) |
Functional Keywords | alpha-beta structure, antibiotic resistance, cell membrane, hydrolase, lipoprotein, membrane, palmitate, hydrolase-antibiotic complex, hydrolase/antibiotic |
Biological source | Mycobacterium tuberculosis |
Total number of polymer chains | 1 |
Total formula weight | 29417.73 |
Authors | Tremblay, L.W.,Fan, F.,Blanchard, J.S. (deposition date: 2010-03-15, release date: 2010-04-14, Last modification date: 2023-09-06) |
Primary citation | Tremblay, L.W.,Fan, F.,Blanchard, J.S. Biochemical and structural characterization of Mycobacterium tuberculosis beta-lactamase with the carbapenems ertapenem and doripenem. Biochemistry, 49:3766-3773, 2010 Cited by PubMed: 20353175DOI: 10.1021/bi100232q PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.3 Å) |
Structure validation
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