3M6B

Crystal Structure of the Ertapenem Pre-isomerized Covalent Adduct with TB B-lactamase

3M6B の概要

• エントリーDOI: 10.2210/pdb3m6b/pdb
• 関連するPDBエントリー: 3M6H 3cg5 3dwz
• 分子名称: Beta-lactamase, PHOSPHATE ION, (4R,5S)-3-({(3S,5S)-5-[(3-carboxyphenyl)carbamoyl]pyrrolidin-3-yl}sulfanyl)-5-[(1S,2R)-1-formyl-2-hydroxypropyl]-4-methyl-4,5-dihydro-1H-pyrrole-2-carboxylic acid, ... (4 entities in total)
• 機能のキーワード: alpha-beta structure, antibiotic resistance, cell membrane, hydrolase, lipoprotein, membrane, palmitate, hydrolase-antibiotic complex, hydrolase/antibiotic
• 由来する生物種: Mycobacterium tuberculosis
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 29417.73

構造登録者

Tremblay, L.W.,Fan, F.,Blanchard, J.S. (登録日: 2010-03-15, 公開日: 2010-04-14, 最終更新日: 2023-09-06)

• 主引用文献: Tremblay, L.W.,Fan, F.,Blanchard, J.S.; Biochemical and structural characterization of Mycobacterium tuberculosis beta-lactamase with the carbapenems ertapenem and doripenem.; Biochemistry, 49:3766-3773, 2010; PubMed: 20353175; DOI: 10.1021/bi100232q

実験手法

X-RAY DIFFRACTION (1.3 Å)