3LXG
Crystal structure of rat phosphodiesterase 10A in complex with ligand WEB-3
Summary for 3LXG
Entry DOI | 10.2210/pdb3lxg/pdb |
Descriptor | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A, 2-methoxy-6,7-dimethyl-9-propylimidazo[1,5-a]pyrido[3,2-e]pyrazine, ZINC ION, ... (5 entities in total) |
Functional Keywords | phosphodiesterase 10a; catalytic domain, allosteric enzyme, camp, camp-binding, cgmp, cgmp-binding, hydrolase, metal-binding, nucleotide-binding |
Biological source | Rattus norvegicus (rat) |
Cellular location | Cytoplasm: Q9QYJ6 |
Total number of polymer chains | 1 |
Total formula weight | 36033.09 |
Authors | Mosbacher, T.,Jestel, A.,Steinbacher, S. (deposition date: 2010-02-25, release date: 2010-05-19, Last modification date: 2024-02-21) |
Primary citation | Hofgen, N.,Stange, H.,Schindler, R.,Lankau, H.J.,Grunwald, C.,Langen, B.,Egerland, U.,Tremmel, P.,Pangalos, M.N.,Marquis, K.L.,Hage, T.,Harrison, B.L.,Malamas, M.S.,Brandon, N.J.,Kronbach, T. Discovery of imidazo[1,5-a]pyrido[3,2-e]pyrazines as a new class of phosphodiesterase 10A inhibitiors. J.Med.Chem., 53:4399-4411, 2010 Cited by PubMed: 20450197DOI: 10.1021/jm1002793 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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