3LXG

Crystal structure of rat phosphodiesterase 10A in complex with ligand WEB-3

3LXG の概要

• エントリーDOI: 10.2210/pdb3lxg/pdb
• 分子名称: cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A, 2-methoxy-6,7-dimethyl-9-propylimidazo[1,5-a]pyrido[3,2-e]pyrazine, ZINC ION, ... (5 entities in total)
• 機能のキーワード: phosphodiesterase 10a; catalytic domain, allosteric enzyme, camp, camp-binding, cgmp, cgmp-binding, hydrolase, metal-binding, nucleotide-binding
• 由来する生物種: Rattus norvegicus (rat)
• 細胞内の位置: Cytoplasm: Q9QYJ6
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 36033.09

構造登録者

Mosbacher, T.,Jestel, A.,Steinbacher, S. (登録日: 2010-02-25, 公開日: 2010-05-19, 最終更新日: 2024-02-21)

• 主引用文献: Hofgen, N.,Stange, H.,Schindler, R.,Lankau, H.J.,Grunwald, C.,Langen, B.,Egerland, U.,Tremmel, P.,Pangalos, M.N.,Marquis, K.L.,Hage, T.,Harrison, B.L.,Malamas, M.S.,Brandon, N.J.,Kronbach, T.; Discovery of imidazo[1,5-a]pyrido[3,2-e]pyrazines as a new class of phosphodiesterase 10A inhibitiors.; J.Med.Chem., 53:4399-4411, 2010; PubMed: 20450197; DOI: 10.1021/jm1002793

実験手法

X-RAY DIFFRACTION (2.3 Å)