E. cloacae MurA dead-end complex with UNAG and fosfomycin

Summary for 3LTH

Related3KQA 3KR6
DescriptorUDP-N-acetylglucosamine 1-carboxyvinyltransferase, [(1R)-1-hydroxypropyl]phosphonic acid, URIDINE-DIPHOSPHATE-N-ACETYLGLUCOSAMINE, ... (4 entities in total)
Functional Keywordsopen enzyme state, inside-out alpha/beta barrel, cell wall biogenesis/degradation, peptidoglycan synthesis, transferase, transferase-antibiotic complex, transferase/antibiotic
Biological sourceEnterobacter cloacae
Cellular locationCytoplasm (Probable) P33038
Total number of polymer chains1
Total molecular weight45576.84
Schonbrunn, E. (deposition date: 2010-02-15, release date: 2010-05-05, Last modification date: 2011-07-27)
Primary citation
Han, H.,Yang, Y.,Olesen, S.H.,Becker, A.,Betzi, S.,Schonbrunn, E.
The fungal product terreic acid is a covalent inhibitor of the bacterial cell wall biosynthetic enzyme UDP-N-acetylglucosamine 1-carboxyvinyltransferase (MurA) .
Biochemistry, 49:4276-4282, 2010
PubMed: 20392080 (PDB entries with the same primary citation)
DOI: 10.1021/bi100365b
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.209602.1%1.0%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 3lth
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Molmil generated image of 3lth
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