MurA dead-end complex with terreic acid

Summary for 3KQA

Related3KQJ 3KR6
DescriptorUDP-N-acetylglucosamine 1-carboxyvinyltransferase, (5S)-2,5-dihydroxy-3-methylcyclohex-2-ene-1,4-dione, CALCIUM ION, ... (4 entities in total)
Functional Keywordsopen enzyme state, inside-out alpha/beta barrel, cell cycle, cell division, cell shape, cell wall biogenesis/degradation, peptidoglycan synthesis, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological sourceEnterobacter cloacae
Cellular locationCytoplasm (Probable) P33038
Total number of polymer chains4
Total molecular weight180342.95
Schonbrunn, E. (deposition date: 2009-11-17, release date: 2010-04-28, Last modification date: 2011-07-27)
Primary citation
Han, H.,Yang, Y.,Olesen, S.H.,Becker, A.,Betzi, S.,Schonbrunn, E.
The fungal product terreic acid is a covalent inhibitor of the bacterial cell wall biosynthetic enzyme UDP-N-acetylglucosamine 1-carboxyvinyltransferase (MurA) .
Biochemistry, 49:4276-4282, 2010
PubMed: 20392080 (PDB entries with the same primary citation)
DOI: 10.1021/bi100365b
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.25570.4%2.6%1.4%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

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