3LTF

Crystal Structure of the Drosophila Epidermal Growth Factor Receptor ectodomain in complex with Spitz

3LTF の概要

• エントリーDOI: 10.2210/pdb3ltf/pdb
• 関連するPDBエントリー: 3I2T 3LTG
• 分子名称: Epidermal growth factor receptor, Protein spitz, alpha-D-mannopyranose-(1-4)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total)
• 機能のキーワード: receptor-ligand complex ectodomain cysteine rich domain egf domain, atp-binding, kinase, nucleotide-binding, receptor, transferase, tyrosine-protein kinase, cell membrane, developmental protein, differentiation, disulfide bond, egf-like domain, endoplasmic reticulum, glycoprotein, golgi apparatus, membrane, neurogenesis, transmembrane, transferase-transferase regulator complex, transferase/transferase regulator
• 由来する生物種: Drosophila melanogaster (Fruit fly); 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 152414.94

構造登録者

Alvarado, D.,Klein, D.E.,Lemmon, M.A. (登録日: 2010-02-15, 公開日: 2010-08-25, 最終更新日: 2023-09-06)

• 主引用文献: Alvarado, D.,Klein, D.E.,Lemmon, M.A.; Structural basis for negative cooperativity in growth factor binding to an EGF receptor.; Cell(Cambridge,Mass.), 142:568-579, 2010; PubMed: 20723758; DOI: 10.1016/j.cell.2010.07.015

実験手法

X-RAY DIFFRACTION (3.2 Å)