3LRG

Structure of anti-huntingtin VL domain

Summary for 3LRG

• Entry DOI: 10.2210/pdb3lrg/pdb
• Related: 3LRH
• Descriptor: anti-huntingtin VL domain, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, IMIDAZOLE, ... (4 entities in total)
• Functional Keywords: huntington's disease, huntingtin, variable light chain domain, intrabody, immunoglobulin, immune system
• Biological source: Homo sapiens
• Total number of polymer chains: 2
• Total formula weight: 25913.17

Authors

Schiefner, A.,Chatwell, L.,Skerra, A. (deposition date: 2010-02-11, release date: 2011-02-23, Last modification date: 2023-09-06)

• Primary citation: Schiefner, A.,Chatwell, L.,Korner, J.,Neumaier, I.,Colby, D.W.,Volkmer, R.,Wittrup, K.D.,Skerra, A.; A Disulfide-Free Single-Domain V(L) Intrabody with Blocking Activity towards Huntingtin Reveals a Novel Mode of Epitope Recognition.; J.Mol.Biol., 414:337-355, 2011; PubMed: 21968397; DOI: 10.1016/j.jmb.2011.09.034

Experimental method

X-RAY DIFFRACTION (2.05 Å)