3LPQ

Human MitoNEET with 2Fe-2S Coordinating Ligand His 87 Replaced With Cys

Summary for 3LPQ

• Entry DOI: 10.2210/pdb3lpq/pdb
• Descriptor: CDGSH iron sulfur domain-containing protein 1, FE2/S2 (INORGANIC) CLUSTER (3 entities in total)
• Functional Keywords: cdgsh protein fold, 2fe-2s cluster, neet fold, homodimer, iron, iron-sulfur, membrane, metal-binding, mitochondrion, mitochondrion outer membrane, signal-anchor, transmembrane, metal binding protein
• Biological source: Homo sapiens (human)
• Cellular location: Mitochondrion outer membrane; Single-pass type III membrane protein: Q9NZ45
• Total number of polymer chains: 2
• Total formula weight: 18803.02

Authors

Conlan, A.R.,Homer, C.,Axelrod, H.L.,Cohen, A.E.,Abresch, E.C.,Zuris, J.,Nechushtai, R.,Paddock, M.L.,Jennings, P.A. (deposition date: 2010-02-05, release date: 2011-06-01, Last modification date: 2024-02-21)

• Primary citation: Conlan, A.R.,Paddock, M.L.,Homer, C.,Axelrod, H.L.,Cohen, A.E.,Abresch, E.C.,Zuris, J.A.,Nechushtai, R.,Jennings, P.A.; Mutation of the His ligand in mitoNEET stabilizes the 2Fe-2S cluster despite conformational heterogeneity in the ligand environment.; Acta Crystallogr.,Sect.D, 67:516-523, 2011; PubMed: 21636891; DOI: 10.1107/S0907444911011577

Experimental method

X-RAY DIFFRACTION (1.7 Å)