3LPQ
Human MitoNEET with 2Fe-2S Coordinating Ligand His 87 Replaced With Cys
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0010506 | biological_process | regulation of autophagy |
| A | 0043231 | cellular_component | intracellular membrane-bounded organelle |
| A | 0051537 | molecular_function | 2 iron, 2 sulfur cluster binding |
| B | 0010506 | biological_process | regulation of autophagy |
| B | 0043231 | cellular_component | intracellular membrane-bounded organelle |
| B | 0051537 | molecular_function | 2 iron, 2 sulfur cluster binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE FES A 500 |
| Chain | Residue |
| A | CYS72 |
| A | ARG73 |
| A | CYS74 |
| A | CYS83 |
| A | ASP84 |
| A | ALA86 |
| A | CYS87 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE FES B 500 |
| Chain | Residue |
| B | CYS74 |
| B | CYS83 |
| B | ASP84 |
| B | ALA86 |
| B | CYS87 |
| B | CYS72 |
| B | ARG73 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | ACT_SITE: Schiff-base intermediate with pyridoxal 5'-phosphate => ECO:0000269|PubMed:36194135 |
| Chain | Residue | Details |
| A | LYS55 | |
| B | LYS55 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 8 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:17766439, ECO:0000269|PubMed:17766440, ECO:0000269|PubMed:17905743, ECO:0007744|PDB:2QD0, ECO:0007744|PDB:2QH7, ECO:0007744|PDB:2R13 |
| Chain | Residue | Details |
| A | CYS72 | |
| A | CYS74 | |
| A | CYS83 | |
| A | CYS87 | |
| B | CYS72 | |
| B | CYS74 | |
| B | CYS83 | |
| B | CYS87 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 6 |
| Details | MOD_RES: N6-acetyllysine; alternate => ECO:0000250|UniProtKB:Q91WS0 |
| Chain | Residue | Details |
| A | LYS55 | |
| A | LYS68 | |
| A | LYS104 | |
| B | LYS55 | |
| B | LYS68 | |
| B | LYS104 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 14 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:25621951 |
| Chain | Residue | Details |
| A | LYS42 | |
| B | LYS78 | |
| B | LYS79 | |
| B | LYS89 | |
| B | LYS105 | |
| B | LYS106 | |
| A | LYS78 | |
| A | LYS79 | |
| A | LYS89 | |
| A | LYS105 | |
| A | LYS106 | |
| B | LYS42 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 6 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate => ECO:0000269|PubMed:25621951 |
| Chain | Residue | Details |
| A | LYS55 | |
| A | LYS68 | |
| A | LYS104 | |
| B | LYS55 | |
| B | LYS68 | |
| B | LYS104 |
