3LPP

Crystal complex of N-terminal sucrase-isomaltase with kotalanol

Summary for 3LPP

Entry DOI	10.2210/pdb3lpp/pdb
Related	3LPO
Descriptor	Sucrase-isomaltase, alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (10 entities in total)
Functional Keywords	glycoside hydrolase family 31, isomaltase, alpha-glucosidase, cell membrane, disease mutation, disulfide bond, glycoprotein, glycosidase, hydrolase, membrane, multifunctional enzyme, polymorphism, signal-anchor, sulfation, transmembrane
Biological source	Homo sapiens (human)
Cellular location	Apical cell membrane; Single-pass type II membrane protein: P14410
Total number of polymer chains	4
Total formula weight	417299.67
Authors	Sim, L.,Rose, D.R. (deposition date: 2010-02-05, release date: 2010-03-31, Last modification date: 2020-07-29)
Primary citation	Sim, L.,Willemsma, C.,Mohan, S.,Naim, H.Y.,Pinto, B.M.,Rose, D.R. Structural basis for substrate selectivity in human maltase-glucoamylase and sucrase-isomaltase N-terminal domains. J.Biol.Chem., 285:17763-17770, 2010 Cited by PubMed: 20356844 DOI: 10.1074/jbc.M109.078980 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.15 Å)

Structure validation