3LPP
Crystal complex of N-terminal sucrase-isomaltase with kotalanol
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D | Sucrase-isomaltase | polymer | 898 | 102867.1 | 4 | UniProt (P14410) Pfam (PF00088) Pfam (PF13802) Pfam (PF01055) Pfam (PF21365) In PDB | Homo sapiens (human) | Sucrase, Isomaltase |
| 2 | E, H | alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 748.7 | 2 | In PDB GlyTouCan (G81315DD) | |||
| 3 | F, G, I | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 3 | In PDB GlyTouCan (G42666HT) | |||
| 4 | A, B, C | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 6 | Chemie (NAG) | |||
| 5 | A, C | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL | non-polymer | 122.1 | 2 | Chemie (TRS) | |||
| 6 | A, B, C, D | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 4 | Chemie (PEG) | |||
| 7 | A | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 8 | B | beta-D-mannopyranose | non-polymer | 180.2 | 1 | Chemie (BMA) | |||
| 9 | B, D | (1S,2R,3R,4S)-1-{(1S)-2-[(2R,3S,4S)-3,4-dihydroxy-2-(hydroxymethyl)tetrahydrothiophenium-1-yl]-1-hydroxyethyl}-2,3,4,5-tetrahydroxypentyl sulfate | non-polymer | 424.4 | 2 | Chemie (KTL) | |||
| 10 | water | water | 18.0 | 1727 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 29 - 898 (UniProt: P14410)
| PDB | External Database | Details |
|---|---|---|
| Arg 1 | - | expression tag |
| Ser 2 | - | expression tag |
| Ser 3 | - | expression tag |
| His 4 | - | expression tag |
| His 5 | - | expression tag |
| His 6 | - | expression tag |
| His 7 | - | expression tag |
| His 8 | - | expression tag |
| His 9 | - | expression tag |
| Gly 10 | - | expression tag |
| Glu 11 | - | expression tag |
| Phe 12 | - | expression tag |
| Asp 13 | - | expression tag |
| Ile 14 | - | expression tag |
| Pro 15 | - | expression tag |
| Thr 16 | - | expression tag |
| Thr 17 | - | expression tag |
| Glu 18 | - | expression tag |
| Asn 19 | - | expression tag |
| Leu 20 | - | expression tag |
| Tyr 21 | - | expression tag |
| Phe 22 | - | expression tag |
| Gln 23 | - | expression tag |
| Ser 24 | - | expression tag |
| Gly 25 | - | expression tag |
| Ile 26 | - | expression tag |
| Arg 27 | - | expression tag |
| Arg 28 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 411468.6 | |
| Branched | Number of molecules | 5 |
| Total formula weight | 2770.6 | |
| Non-Polymers* | Number of molecules | 16 |
| Total formula weight | 3060.5 | |
| All* | Total formula weight | 417299.7 |
