3LP0

HIV-1 reverse transcriptase with inhibitor

Summary for 3LP0

• Entry DOI: 10.2210/pdb3lp0/pdb
• Related: 3LP1 3LP2 3LP3
• Descriptor: Reverse transcriptase/ribonuclease H, p51 RT, MANGANESE (II) ION, ... (6 entities in total)
• Functional Keywords: reverse transcriptase, rnase h, hiv, aids, dna-directed dna polymerase, endonuclease, host cytoplasm, host nucleus, host-virus interaction, hydrolase, magnesium, metal-binding, multifunctional enzyme, nuclease, nucleotidyltransferase, rna-binding, rna-directed dna polymerase, transferase, viral nucleoprotein, virion, transferase-hydrolase complex, transferase/hydrolase
• Biological source: Human immunodeficiency virus type 1 (HIV-1); More
• Cellular location: Gag-Pol polyprotein: Host cell membrane; Lipid-anchor . Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P04585 P04585
• Total number of polymer chains: 2
• Total formula weight: 117224.97

Authors

Yan, Y.,Munshi, S.K.,Prasad, G.S.,Su, H.P. (deposition date: 2010-02-04, release date: 2010-06-09, Last modification date: 2024-02-21)

• Primary citation: Su, H.P.,Yan, Y.,Prasad, G.S.,Smith, R.F.,Daniels, C.L.,Abeywickrema, P.D.,Reid, J.C.,Loughran, H.M.,Kornienko, M.,Sharma, S.,Grobler, J.A.,Xu, B.,Sardana, V.,Allison, T.J.,Williams, P.D.,Darke, P.L.,Hazuda, D.J.,Munshi, S.; Structural basis for the inhibition of RNase H activity of HIV-1 reverse transcriptase by RNase H active site-directed inhibitors.; J.Virol., 84:7625-7633, 2010; PubMed: 20484498; DOI: 10.1128/JVI.00353-10

Experimental method

X-RAY DIFFRACTION (2.79 Å)