3LOK

Drug resistant cSrc kinase domain in complex with covalent inhibitor PD168393

Summary for 3LOK

Entry DOI	10.2210/pdb3lok/pdb
Related	2HWP 2QI8 2QLQ 2QQ7
Descriptor	Proto-oncogene tyrosine-protein kinase Src, N-[4-(3-BROMO-PHENYLAMINO)-QUINAZOLIN-6-YL]-ACRYLAMIDE (3 entities in total)
Functional Keywords	src kinase domain, drug resistance, irreversible inhibitor, covalent inhibitor, pd168393, atp-binding, kinase, lipoprotein, myristate, nucleotide-binding, phosphoprotein, proto-oncogene, sh2 domain, sh3 domain, tyrosine-protein kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Gallus gallus (chicken)
Cellular location	Cell membrane (By similarity): P00523
Total number of polymer chains	2
Total formula weight	66284.03
Authors	Gruetter, C.,Rode, H.B.,Rauh, D. (deposition date: 2010-02-04, release date: 2010-12-22, Last modification date: 2023-11-01)
Primary citation	Klueter, S.,Simard, J.R.,Rode, H.B.,Gruetter, C.,Pawar, V.,Raaijmakers, H.C.,Barf, T.A.,Rabiller, M.,van Otterlo, W.A.L.,Rauh, D. Characterization of irreversible kinase inhibitors by directly detecting covalent bond formation: a tool for dissecting kinase drug resistance Chembiochem, 11:2557-2566, 2010 Cited by PubMed: 21080395 DOI: 10.1002/cbic.201000352 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.48 Å)

Structure validation