3LOK

Drug resistant cSrc kinase domain in complex with covalent inhibitor PD168393

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Proto-oncogene tyrosine-protein kinase Src	polymer	286	32772.8	2	UniProt (P00523) Pfam (PF07714)	Gallus gallus (chicken)	pp60c-src, p60-Src, c-Src
2	C, D (A, B)	N-[4-(3-BROMO-PHENYLAMINO)-QUINAZOLIN-6-YL]-ACRYLAMIDE	non-polymer		369.2	2	Chemie (DJK)
3	E, F (A, B)	water	water		18.0	63	Chemie (HOH)

Sequence modifications

A, B: 251 - 533 (UniProt: P00523)

PDB	External Database	Details
Gly 248	-	expression tag
His 249	-	expression tag
Met 250	-	expression tag
Met 338	Thr 338	engineered mutation
Cys 345	Ser 345	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	65545.6
Non-Polymers*	Number of molecules	2
	Total formula weight	738.4
All*	Total formula weight	66284.0

*Water molecules are not included.