2HWP

Crystal structure of Src kinase domain in complex with covalent inhibitor PD168393

Summary for 2HWP

Entry DOI	10.2210/pdb2hwp/pdb
Related	2HWO
Descriptor	Proto-oncogene tyrosine-protein kinase Src, N-[4-(3-BROMO-PHENYLAMINO)-QUINAZOLIN-6-YL]-ACRYLAMIDE (3 entities in total)
Functional Keywords	kinase, covalent, quinazoline, modification, transferase
Biological source	Gallus gallus (chicken)
Cellular location	Cell membrane : P00523
Total number of polymer chains	2
Total formula weight	66223.85
Authors	Rauh, D.,Blair, J.A.,Shokat, K.M. (deposition date: 2006-08-01, release date: 2007-02-27, Last modification date: 2021-10-20)
Primary citation	Blair, J.A.,Rauh, D.,Kung, C.,Yun, C.H.,Fan, Q.W.,Rode, H.,Zhang, C.,Eck, M.J.,Weiss, W.A.,Shokat, K.M. Structure-guided development of affinity probes for tyrosine kinases using chemical genetics. Nat.Chem.Biol., 3:229-238, 2007 Cited by PubMed: 17334377 DOI: 10.1038/nchembio866 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.48 Å)

Structure validation