2HWP
Crystal structure of Src kinase domain in complex with covalent inhibitor PD168393
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Proto-oncogene tyrosine-protein kinase Src | polymer | 286 | 32742.7 | 2 | UniProt (P00523) Pfam (PF07714) | Gallus gallus (chicken) | p60-Src, c-Src, pp60c-src |
| 2 | C, D (A, B) | N-[4-(3-BROMO-PHENYLAMINO)-QUINAZOLIN-6-YL]-ACRYLAMIDE | non-polymer | 369.2 | 2 | Chemie (DJK) | |||
| 3 | E, F (A, B) | water | water | 18.0 | 30 | Chemie (HOH) |
Sequence modifications
A, B: 251 - 533 (UniProt: P00523)
| PDB | External Database | Details |
|---|---|---|
| Gly 248 | - | cloning artifact |
| His 249 | - | cloning artifact |
| Met 250 | - | cloning artifact |
| Cys 345 | Ser 344 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 65485.4 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 738.4 | |
| All* | Total formula weight | 66223.9 |
