3LOK

Drug resistant cSrc kinase domain in complex with covalent inhibitor PD168393

3LOK の概要

• エントリーDOI: 10.2210/pdb3lok/pdb
• 関連するPDBエントリー: 2HWP 2QI8 2QLQ 2QQ7
• 分子名称: Proto-oncogene tyrosine-protein kinase Src, N-[4-(3-BROMO-PHENYLAMINO)-QUINAZOLIN-6-YL]-ACRYLAMIDE (3 entities in total)
• 機能のキーワード: src kinase domain, drug resistance, irreversible inhibitor, covalent inhibitor, pd168393, atp-binding, kinase, lipoprotein, myristate, nucleotide-binding, phosphoprotein, proto-oncogene, sh2 domain, sh3 domain, tyrosine-protein kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Gallus gallus (chicken)
• 細胞内の位置: Cell membrane (By similarity): P00523
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 66284.03

構造登録者

Gruetter, C.,Rode, H.B.,Rauh, D. (登録日: 2010-02-04, 公開日: 2010-12-22, 最終更新日: 2023-11-01)

• 主引用文献: Klueter, S.,Simard, J.R.,Rode, H.B.,Gruetter, C.,Pawar, V.,Raaijmakers, H.C.,Barf, T.A.,Rabiller, M.,van Otterlo, W.A.L.,Rauh, D.; Characterization of irreversible kinase inhibitors by directly detecting covalent bond formation: a tool for dissecting kinase drug resistance; Chembiochem, 11:2557-2566, 2010; PubMed: 21080395; DOI: 10.1002/cbic.201000352

実験手法

X-RAY DIFFRACTION (2.48 Å)