3LNJ

Crystal structure of human MDM2 in complex with D-peptide inhibitor (DPMI-alpha)

3LNJ の概要

• エントリーDOI: 10.2210/pdb3lnj/pdb
• 関連するPDBエントリー: 1YCR 3EQS 3IUX 3IWY
• 関連するBIRD辞書のPRD_ID: PRD_000808
• 分子名称: E3 ubiquitin-protein ligase Mdm2, D-peptide inhibitor, SULFATE ION, ... (6 entities in total)
• 機能のキーワード: mdm2, p53 binding domain, d-peptide activator of mdm2, mdm2-d-peptide complex, host-virus interaction, ligase, metal-binding, nucleus, phosphoprotein, proto-oncogene, ubl conjugation pathway, zinc-finger, ligase-ligase inhibitor complex, ligase/ligase inhibitor
• 細胞内の位置: Nucleus, nucleoplasm: Q00987
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 34923.50

構造登録者

Pazgier, M.,Lu, W. (登録日: 2010-02-02, 公開日: 2010-03-09, 最終更新日: 2024-11-06)

主引用文献

Liu, M.,Pazgier, M.,Li, C.,Yuan, W.,Li, C.,Lu, W.
A left-handed solution to peptide inhibition of the p53-MDM2 interaction.
Angew.Chem.Int.Ed.Engl., 49:3649-3652, 2010

PubMed Abstract: [Image: see text] The oncoprotein MDM2 negatively regulates the activity and stability of the tumor suppressor protein p53, and is an important molecular target for anticancer therapy. Mirror image phage display identifies a high-affinity D-peptide ligand of MDM2 that can be developed into a potent and protease-resistant p53 activator with potential antitumor activity.

PubMed: 20449836
DOI: 10.1002/anie.201000329

実験手法

X-RAY DIFFRACTION (2.4 Å)