3LMS
Structure of human activated thrombin-activatable fibrinolysis inhibitor, TAFIa, in complex with tick-derived funnelin inhibitor, TCI.
Summary for 3LMS
| Entry DOI | 10.2210/pdb3lms/pdb |
| Related | 3d4u 3d66 3d6v |
| Descriptor | Carboxypeptidase B2, Carboxypeptidase inhibitor, ZINC ION, ... (9 entities in total) |
| Functional Keywords | fibrinolysis, cogaulation, funnelin, alpha-beta-hydrolase, metallopeptidase, alternative splicing, carboxypeptidase, disulfide bond, glycoprotein, hydrolase, metal-binding, metalloprotease, polymorphism, protease, secreted, zinc, zymogen, blood coagulation, metalloenzyme inhibitor, metalloprotease inhibitor, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
| Biological source | Rhipicephalus bursa More |
| Cellular location | Secreted: Q96IY4 Q5EPH2 |
| Total number of polymer chains | 2 |
| Total formula weight | 44375.88 |
| Authors | Sanglas, L.,Arolas, J.L.,Valnickova, Z.,Aviles, F.X.,Enghild, J.J.,Gomis-Ruth, F.X. (deposition date: 2010-02-01, release date: 2010-02-16, Last modification date: 2024-11-13) |
| Primary citation | Sanglas, L.,Arolas, J.L.,Valnickova, Z.,Aviles, F.X.,Enghild, J.J.,Gomis-Ruth, F.X. Insights into the molecular inactivation mechanism of human activated thrombin-activatable fibrinolysis inhibitor J.Thromb.Haemost., 8:1056-1065, 2010 Cited by PubMed Abstract: Thrombin-activatable fibrinolysis inhibitor (TAFI) is a validated target for thrombotic diseases. TAFI is converted in vivo to activated TAFI (TAFIa) by removal of its pro-domain. Whereas TAFI is stable and persists in the circulation, possibly in complex with plasminogen, TAFIa is unstable and poorly soluble, with a half-life of minutes. PubMed: 20088943DOI: 10.1111/j.1538-7836.2010.03740.x PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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