3LJ6

3D-CRYSTAL STRUCTURE OF HUMANIZED-RAT FATTY ACID AMIDE HYDROLASE (FAAH) CONJUGATED WITH THE DRUG-LIKE UREA INHIBITOR PF-3845 at 2.42A RESOLUTION

3LJ6 の概要

• エントリーDOI: 10.2210/pdb3lj6/pdb
• 関連するPDBエントリー: 2vya 2wap 3LJ7
• 分子名称: Fatty-acid amide hydrolase 1, 4-(3-{[5-(trifluoromethyl)pyridin-2-yl]oxy}benzyl)piperidine-1-carboxylic acid, CHLORIDE ION, ... (4 entities in total)
• 機能のキーワード: protein-inhibitor complex, faah, fatty acid amide hydrolase, urea, inhibitor, covalent, endoplasmic reticulum, golgi apparatus, membrane, transmembrane, hydrolase
• 由来する生物種: Rattus norvegicus (rat)
• 細胞内の位置: Endoplasmic reticulum membrane; Single-pass membrane protein: P97612
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 127019.50

構造登録者

Mileni, M.,Stevens, R.C.,Kamtekar, S. (登録日: 2010-01-25, 公開日: 2010-06-09, 最終更新日: 2023-09-06)

• 主引用文献: Mileni, M.,Kamtekar, S.,Wood, D.C.,Benson, T.E.,Cravatt, B.F.,Stevens, R.C.; Crystal structure of fatty acid amide hydrolase bound to the carbamate inhibitor URB597: discovery of a deacylating water molecule and insight into enzyme inactivation; J.Mol.Biol., 400:743-754, 2010; PubMed: 20493882; DOI: 10.1016/j.jmb.2010.05.034

実験手法

X-RAY DIFFRACTION (2.42 Å)