3LHU

Crystal structure of the mutant I199F of orotidine 5'-monophosphate decarboxylase from Methanobacterium thermoautotrophicum complexed with inhibitor BMP

3LHU の概要

• エントリーDOI: 10.2210/pdb3lhu/pdb
• 関連するPDBエントリー: 3LHT 3LHV 3LHW 3LHY 3LHZ 3LI0 3LI1
• 分子名称: Orotidine 5'-phosphate decarboxylase, 1-(5'-PHOSPHO-BETA-D-RIBOFURANOSYL)BARBITURIC ACID (3 entities in total)
• 機能のキーワード: mutant i199f, 6-hydroxyuridine-5'-phosphate, decarboxylase, pyrimidine biosynthesis, lyase
• 由来する生物種: Methanothermobacter thermautotrophicus
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 50517.79

構造登録者

Fedorov, A.A.,Fedorov, E.V.,Wood, B.M.,Gerlt, J.A.,Almo, S.C. (登録日: 2010-01-23, 公開日: 2010-06-16, 最終更新日: 2023-09-06)

• 主引用文献: Wood, B.M.,Amyes, T.L.,Fedorov, A.A.,Fedorov, E.V.,Shabila, A.,Almo, S.C.,Richard, J.P.,Gerlt, J.A.; Conformational changes in orotidine 5'-monophosphate decarboxylase: "remote" residues that stabilize the active conformation.; Biochemistry, 49:3514-3516, 2010; PubMed: 20369850; DOI: 10.1021/bi100443a

実験手法

X-RAY DIFFRACTION (1.6 Å)