3LHJ

Crystal Structure of p38a Mitogen-Activated Protein Kinase in Complex with a Pyrazolopyridinone Inhibitor.

3LHJ の概要

• エントリーDOI: 10.2210/pdb3lhj/pdb
• 関連するPDBエントリー: 1YQJ 3DS6 3DT1 3GFE 3ITZ
• 分子名称: Mitogen-activated protein kinase 14, N-cyclopropyl-3-[1-(2,4-difluorophenyl)-7-methyl-6-oxo-6,7-dihydro-1H-pyrazolo[3,4-b]pyridin-5-yl]-4-methylbenzamide (3 entities in total)
• 機能のキーワード: serine/threonine-protein kinase, transferase, alternative splicing, atp-binding, cytoplasm, kinase, nucleotide-binding, nucleus, phosphoprotein, polymorphism
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm (By similarity): Q16539
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 42433.38

構造登録者

Mohr, C.,Jordan, S. (登録日: 2010-01-22, 公開日: 2010-04-14, 最終更新日: 2024-02-21)

• 主引用文献: Pettus, L.H.,Wurz, R.P.,Xu, S.,Herberich, B.,Henkle, B.,Liu, Q.,McBride, H.J.,Mu, S.,Plant, M.H.,Saris, C.J.,Sherman, L.,Wong, L.M.,Chmait, S.,Lee, M.R.,Mohr, C.,Hsieh, F.,Tasker, A.S.; Discovery and evaluation of 7-alkyl-1,5-bis-aryl-pyrazolopyridinones as highly potent, selective, and orally efficacious inhibitors of p38alpha mitogen-activated protein kinase.; J.Med.Chem., 53:2973-2985, 2010; PubMed: 20218619; DOI: 10.1021/jm100095x

実験手法

X-RAY DIFFRACTION (3.31 Å)