3LGZ
Crystal structure of dehydrosqualene synthase Y129A from S. aureus complexed with presqualene pyrophosphate
Summary for 3LGZ
Entry DOI | 10.2210/pdb3lgz/pdb |
Descriptor | Dehydrosqualene synthase, {(1R,2R,3R)-2-[(3E)-4,8-dimethylnona-3,7-dien-1-yl]-2-methyl-3-[(1E,5E)-2,6,10-trimethylundeca-1,5,9-trien-1-yl]cyclopropyl}methyl trihydrogen diphosphate, MAGNESIUM ION, ... (4 entities in total) |
Functional Keywords | c30 carotenoid, virulence factor, presqualene diphosphate, pspp, transferase |
Biological source | Staphylococcus aureus |
Total number of polymer chains | 1 |
Total formula weight | 35330.69 |
Authors | Lin, F.-Y.,Liu, Y.-L.,Liu, C.-I.,Wang, A.H.J.,Oldfield, E. (deposition date: 2010-01-21, release date: 2010-12-22, Last modification date: 2023-09-06) |
Primary citation | Lin, F.Y.,Liu, C.I.,Liu, Y.L.,Zhang, Y.,Wang, K.,Jeng, W.Y.,Ko, T.P.,Cao, R.,Wang, A.H.,Oldfield, E. Mechanism of action and inhibition of dehydrosqualene synthase. Proc.Natl.Acad.Sci.USA, 107:21337-21342, 2010 Cited by PubMed: 21098670DOI: 10.1073/pnas.1010907107 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.41 Å) |
Structure validation
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