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3LGZ

Crystal structure of dehydrosqualene synthase Y129A from S. aureus complexed with presqualene pyrophosphate

Summary for 3LGZ
Entry DOI10.2210/pdb3lgz/pdb
DescriptorDehydrosqualene synthase, {(1R,2R,3R)-2-[(3E)-4,8-dimethylnona-3,7-dien-1-yl]-2-methyl-3-[(1E,5E)-2,6,10-trimethylundeca-1,5,9-trien-1-yl]cyclopropyl}methyl trihydrogen diphosphate, MAGNESIUM ION, ... (4 entities in total)
Functional Keywordsc30 carotenoid, virulence factor, presqualene diphosphate, pspp, transferase
Biological sourceStaphylococcus aureus
Total number of polymer chains1
Total formula weight35330.69
Authors
Lin, F.-Y.,Liu, Y.-L.,Liu, C.-I.,Wang, A.H.J.,Oldfield, E. (deposition date: 2010-01-21, release date: 2010-12-22, Last modification date: 2023-09-06)
Primary citationLin, F.Y.,Liu, C.I.,Liu, Y.L.,Zhang, Y.,Wang, K.,Jeng, W.Y.,Ko, T.P.,Cao, R.,Wang, A.H.,Oldfield, E.
Mechanism of action and inhibition of dehydrosqualene synthase.
Proc.Natl.Acad.Sci.USA, 107:21337-21342, 2010
Cited by
PubMed: 21098670
DOI: 10.1073/pnas.1010907107
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.41 Å)
Structure validation

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