3LAW

Structure of GTP-bound L129F mutant Rab7

3LAW の概要

• エントリーDOI: 10.2210/pdb3law/pdb
• 分子名称: Ras-related protein Rab-7a, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ... (4 entities in total)
• 機能のキーワード: protein - nucleotide complex, protein mutant, charcot-marie-tooth disease, cytoplasmic vesicle, disease mutation, endosome, gtp-binding, lipoprotein, lysosome, methylation, neuropathy, nucleotide-binding, phosphoprotein, prenylation, protein transport, proton transport
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Late endosome: P51149
• タンパク質・核酸の鎖数: 5
• 化学式量合計: 120486.17

構造登録者

McCray, B.A.,Skordalakes, E.,Taylor, J.P. (登録日: 2010-01-07, 公開日: 2010-01-26, 最終更新日: 2024-02-21)

• 主引用文献: McCray, B.A.,Skordalakes, E.,Taylor, J.P.; Disease mutations in Rab7 result in unregulated nucleotide exchange and inappropriate activation.; Hum.Mol.Genet., 19:1033-1047, 2010; PubMed: 20028791; DOI: 10.1093/hmg/ddp567

実験手法

X-RAY DIFFRACTION (2.8 Å)