3LAQ

Structure-based engineering of species selectivity in the uPA-uPAR interaction

3LAQ の概要

• エントリーDOI: 10.2210/pdb3laq/pdb
• 関連するPDBエントリー: 2FAT 2FD6 3BT1 3BT2
• 分子名称: Urokinase-type plasminogen activator, Urokinase plasminogen activator surface receptor, 2-acetamido-2-deoxy-beta-D-glucopyranose (3 entities in total)
• 機能のキーワード: upa, upar, atf, supar, smupar, matf, disulfide bond, egf-like domain, hydrolase, kringle, plasminogen activation, protease, secreted, serine protease, zymogen, cell membrane, glycoprotein, gpi-anchor, lipoprotein, membrane, receptor, hydrolase-hydrolase receptor complex, hydrolase/hydrolase receptor
• 由来する生物種: Mus musculus (mouse); 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 92549.57

構造登録者

Huang, M. (登録日: 2010-01-06, 公開日: 2010-02-02, 最終更新日: 2020-07-29)

• 主引用文献: Lin, L.,Gardsvoll, H.,Huai, Q.,Huang, M.,Ploug, M.; Structure-based engineering of species selectivity in the interaction between urokinase and its receptor: implication for preclinical cancer therapy.; J.Biol.Chem., 285:10982-10992, 2010; PubMed: 20133942; DOI: 10.1074/jbc.M109.093492

実験手法

X-RAY DIFFRACTION (3.2 Å)