3L8S
Human p38 MAP Kinase in Complex with CP-547632
Summary for 3L8S
Entry DOI | 10.2210/pdb3l8s/pdb |
Related | 3HUB 3HUC |
Descriptor | Mitogen-activated protein kinase 14, octyl beta-D-glucopyranoside, 3-[(4-bromo-2,6-difluorobenzyl)oxy]-5-{[(4-pyrrolidin-1-ylbutyl)carbamoyl]amino}isothiazole-4-carboxamide, ... (4 entities in total) |
Functional Keywords | dfg-out, glycine-rich loop, cp-547632, alternative splicing, atp-binding, cytoplasm, kinase, nucleotide-binding, nucleus, phosphoprotein, polymorphism, serine/threonine-protein kinase, transferase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 42059.74 |
Authors | Gruetter, C.,Simard, J.R.,Rauh, D. (deposition date: 2010-01-03, release date: 2010-03-09, Last modification date: 2024-02-21) |
Primary citation | Simard, J.R.,Getlik, M.,Grutter, C.,Schneider, R.,Wulfert, S.,Rauh, D. Fluorophore labeling of the glycine-rich loop as a method of identifying inhibitors that bind to active and inactive kinase conformations. J.Am.Chem.Soc., 132:4152-4160, 2010 Cited by PubMed: 20201574DOI: 10.1021/ja908083e PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.35 Å) |
Structure validation
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