3L8S

Human p38 MAP Kinase in Complex with CP-547632

Summary for 3L8S

Entry DOI	10.2210/pdb3l8s/pdb
Related	3HUB 3HUC
Descriptor	Mitogen-activated protein kinase 14, octyl beta-D-glucopyranoside, 3-[(4-bromo-2,6-difluorobenzyl)oxy]-5-{[(4-pyrrolidin-1-ylbutyl)carbamoyl]amino}isothiazole-4-carboxamide, ... (4 entities in total)
Functional Keywords	dfg-out, glycine-rich loop, cp-547632, alternative splicing, atp-binding, cytoplasm, kinase, nucleotide-binding, nucleus, phosphoprotein, polymorphism, serine/threonine-protein kinase, transferase
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	42059.74
Authors	Gruetter, C.,Simard, J.R.,Rauh, D. (deposition date: 2010-01-03, release date: 2010-03-09, Last modification date: 2024-02-21)
Primary citation	Simard, J.R.,Getlik, M.,Grutter, C.,Schneider, R.,Wulfert, S.,Rauh, D. Fluorophore labeling of the glycine-rich loop as a method of identifying inhibitors that bind to active and inactive kinase conformations. J.Am.Chem.Soc., 132:4152-4160, 2010 Cited by PubMed: 20201574 DOI: 10.1021/ja908083e PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.35 Å)

Structure validation