3L8P

Crystal structure of cytoplasmic kinase domain of Tie2 complexed with inhibitor CEP11207

3L8P の概要

• エントリーDOI: 10.2210/pdb3l8p/pdb
• 関連するPDBエントリー: 1FVR
• 分子名称: Angiopoietin-1 receptor, 2-methyl-11-(1-methylethyl)-8-[(2S)-tetrahydro-2H-pyran-2-yl]-2,11,12,13-tetrahydro-4H-indazolo[5,4-a]pyrrolo[3,4-c]carbazol-4-one (3 entities in total)
• 機能のキーワード: receptor tyrosine kinase, cytoplasmic kinase domain, tie2, inhibitor cep11207, atp-binding, disease mutation, glycoprotein, kinase, membrane, nucleotide-binding, phosphoprotein, receptor, transferase, tyrosine-protein kinase
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Membrane; Single-pass type I membrane protein: Q02763
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 36705.88

構造登録者

Fedorov, A.A.,Fedorov, E.V.,Pauletti, D.,Meyer, S.L.,Hudkins, R.L.,Almo, S.C. (登録日: 2010-01-03, 公開日: 2010-10-06, 最終更新日: 2023-09-06)

• 主引用文献: Fedorov, A.A.,Fedorov, E.V.,Pauletti, D.,Meyer, S.L.,Hudkins, R.L.,Almo, S.C.; Crystal structure of cytoplasmic kinase domain of Tie2 complexed with inhibitor CEP11207; To be Published,

実験手法

X-RAY DIFFRACTION (2.4 Å)