3L7A

Crystal Structure of Glycogen Phosphorylase DK2 complex

Summary for 3L7A

Entry DOI	10.2210/pdb3l7a/pdb
Related	3L79 3L7B 3L7C 3L7D
Descriptor	Glycogen phosphorylase, muscle form, 1-(3-deoxy-3-fluoro-beta-D-glucopyranosyl)-4-[(phenylcarbonyl)amino]pyrimidin-2(1H)-one (3 entities in total)
Functional Keywords	glycogenolysis, type 2 diabetes, allosteric enzyme, carbohydrate metabolism, glycogen metabolism, glycosyltransferase, nucleotide-binding, phosphorylation, pyridoxal phosphate, transferase, phosphoprotein
Biological source	Oryctolagus cuniculus (European rabbit,Japanese white rabbit,domestic rabbit,rabbits)
Total number of polymer chains	1
Total formula weight	98029.86
Authors	Tsirkone, V.G.,Lamprakis, C.,Hayes, J.M.,Skamnaki, V.,Drakou, C.,Zographos, S.E.,Leonidas, D.D. (deposition date: 2009-12-28, release date: 2010-10-20, Last modification date: 2023-11-22)
Primary citation	Tsirkone, V.G.,Tsoukala, E.,Lamprakis, C.,Manta, S.,Hayes, J.M.,Skamnaki, V.T.,Drakou, C.,Zographos, S.E.,Komiotis, D.,Leonidas, D.D. 1-(3-Deoxy-3-fluoro-beta-d-glucopyranosyl) pyrimidine derivatives as inhibitors of glycogen phosphorylase b: Kinetic, crystallographic and modelling studies. Bioorg.Med.Chem., 18:3413-3425, 2010 Cited by PubMed: 20430629 DOI: 10.1016/j.bmc.2010.04.004 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation