3L7D
Crystal Structure of Glycogen Phosphorylase DK5 complex
Summary for 3L7D
Entry DOI | 10.2210/pdb3l7d/pdb |
Related | 3L79 3L7A 3L7B 3L7C |
Descriptor | Glycogen phosphorylase, muscle form, 1-(2,3-dideoxy-3-fluoro-beta-D-arabino-hexopyranosyl)-4-[(phenylcarbonyl)amino]pyrimidin-2(1H)-one (3 entities in total) |
Functional Keywords | glycogenolysis, type 2 diabetes, allosteric enzyme, carbohydrate metabolism, glycogen metabolism, glycosyltransferase, nucleotide-binding, phosphorylation, pyridoxal phosphate, transferase, phosphoprotein |
Biological source | Oryctolagus cuniculus (European rabbit,Japanese white rabbit,domestic rabbit,rabbits) |
Total number of polymer chains | 1 |
Total formula weight | 98013.86 |
Authors | Tsirkone, V.G.,Lamprakis, C.,Hayes, J.M.,Skamnaki, V.,Drakou, C.,Zographos, S.E.,Leonidas, D.D. (deposition date: 2009-12-28, release date: 2010-10-20, Last modification date: 2023-11-22) |
Primary citation | Tsirkone, V.G.,Tsoukala, E.,Lamprakis, C.,Manta, S.,Hayes, J.M.,Skamnaki, V.T.,Drakou, C.,Zographos, S.E.,Komiotis, D.,Leonidas, D.D. 1-(3-Deoxy-3-fluoro-beta-d-glucopyranosyl) pyrimidine derivatives as inhibitors of glycogen phosphorylase b: Kinetic, crystallographic and modelling studies. Bioorg.Med.Chem., 18:3413-3425, 2010 Cited by PubMed: 20430629DOI: 10.1016/j.bmc.2010.04.004 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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