3L38
Bace1 in complex with the aminopyridine Compound 44
Summary for 3L38
Entry DOI | 10.2210/pdb3l38/pdb |
Related | 3L3A |
Descriptor | Beta-secretase 1, 6-({2-(2-chlorophenyl)-5-[4-(pyrimidin-5-yloxy)phenyl]-1H-pyrrol-1-yl}methyl)pyridin-2-amine (3 entities in total) |
Functional Keywords | beta-secretase, bace-1, aminopyridine, inhibitor, aspartyl protease, disulfide bond, protease, transmembrane, zymogen, hydrolase |
Biological source | Homo sapiens (human) |
Cellular location | Membrane; Single-pass type I membrane protein: P56817 |
Total number of polymer chains | 1 |
Total formula weight | 46894.90 |
Authors | Olland, A.M.,Chopra, R. (deposition date: 2009-12-16, release date: 2010-04-28, Last modification date: 2023-09-06) |
Primary citation | Malamas, M.S.,Barnes, K.,Hui, Y.,Johnson, M.,Lovering, F.,Condon, J.,Fobare, W.,Solvibile, W.,Turner, J.,Hu, Y.,Manas, E.S.,Fan, K.,Olland, A.,Chopra, R.,Bard, J.,Pangalos, M.N.,Reinhart, P.,Robichaud, A.J. Novel pyrrolyl 2-aminopyridines as potent and selective human beta-secretase (BACE1) inhibitors. Bioorg.Med.Chem.Lett., 20:2068-2073, 2010 Cited by PubMed: 20223661DOI: 10.1016/j.bmcl.2010.02.075 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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