3L26

Crystal structure of Zaire Ebola VP35 interferon inhibitory domain bound to 8 bp dsRNA

3L26 の概要

• エントリーDOI: 10.2210/pdb3l26/pdb
• 関連するPDBエントリー: 3FKE 3L25 3L27 3L28 3L29 3L2A
• 分子名称: Polymerase cofactor VP35, RNA (5'-R(*CP*GP*CP*AP*UP*GP*CP*G)-3'), MAGNESIUM ION, ... (5 entities in total)
• 機能のキーワード: rna binding domain, interferon antiviral evasion, rna replication, rna binding protein, transcription, host cytoplasm, interferon antiviral system evasion, rna-binding, virion, rna binding protein-rna complex, rna binding protein/rna
• 由来する生物種: Zaire ebolavirus (ZEBOV)
• 細胞内の位置: Virion: Q05127
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 31261.41

構造登録者

Leung, D.W.,Prins, K.C.,Borek, D.M.,Farahbakhsh, M.,Tufariello, J.M.,Ramanan, P.,Nix, J.C.,Helgeson, L.A.,Otwinowski, Z.,Honzatko, R.B.,Basler, C.F.,Amarasinghe, G.K. (登録日: 2009-12-14, 公開日: 2010-01-26, 最終更新日: 2023-09-06)

• 主引用文献: Leung, D.W.,Prins, K.C.,Borek, D.M.,Farahbakhsh, M.,Tufariello, J.M.,Ramanan, P.,Nix, J.C.,Helgeson, L.A.,Otwinowski, Z.,Honzatko, R.B.,Basler, C.F.,Amarasinghe, G.K.; Structural basis for dsRNA recognition and interferon antagonism by Ebola VP35.; Nat.Struct.Mol.Biol., 17:165-172, 2010; PubMed: 20081868; DOI: 10.1038/nsmb.1765

実験手法

X-RAY DIFFRACTION (2.4 Å)